IFT Complex: Protein-Protein Interaction That Facilitates Organelle Transport

Target Name: Intraflagellar transport complex

NCBI ID: P18667

Intraflagellar transport complex

Other Name(s): IFT complex | Intraflagellar transport particle

IFT Complex: Protein-Protein Interaction That Facilitates Organelle Transport

Intraflagellar transport complex (IFT complex) is a protein complex that plays a critical role in the transport of organelles, including mitochondria and endoplasmic reticulum, within cells. The IFT complex is composed of several proteins that work together to ensure efficient and accurate transport of these organelles.

IFT complex is a protein-protein interaction (PPI) complex, which means that it consists of two or more proteins that interact with each other to perform specific functions. The IFT complex is a subset of the PPI complex, known as the transmembrane protein (TM) superfamily. This family includes proteins that span the cell membrane and are involved in various cellular processes, including intracellular signaling, protein transport, and cell signaling.

IFT complex is a well-established protein complex that has been studied extensively in the scientific literature. It is involved in the transport of mitochondrial organelles, including mitochondrial protein export, import, and traffic. It also plays a key role in the transport of endoplasmic reticulum (ER) proteins, including protein import and export. In addition, IFT complex is involved in the transport of vesicle-associated protein (VAP) molecules, which are involved in intracellular signaling and are targeted to various cellular organelles.

IFT complex is composed of several proteins that work together to ensure efficient and accurate transport of organelles. The most well-studied protein in the IFT complex is the protein known as IFT-1 (intraflagellar transport complex subunit 1). IFT-1 is a 21-kDa protein that is involved in the transport of mitochondrial protein import and export. It consists of a N-terminal transmembrane domain, a coiled-coil region, and a C-terminal T-spike domain.

The N-terminal transmembrane domain of IFT-1 is responsible for the protein's ability to interact with the cytoplasmic side of the membrane. It is involved in the formation of the protein-protein interaction interface and is involved in the regulation of protein import and export. The coiled-coil region of IFT-1 is responsible for the protein's stability and stability. It is also involved in the regulation of protein import and export.

The C-terminal T-spike domain of IFT-1 is responsible for the protein's ability to interact with the intracellular side of the membrane. It is involved in the regulation of protein import and export and is thought to play a key role in the regulation of intracellular signaling.

IFT complex is also composed of the protein known as IFT-2 (intraflagellar transport complex subunit 2), which is a 22-kDa protein that is involved in the transport of ER protein import and export. It consists of a N-terminal transmembrane domain, a coiled-coil region, and a C-terminal T-spike domain.

The N-terminal transmembrane domain of IFT-2 is responsible for the protein's ability to interact with the cytoplasmic side of the membrane. It is involved in the formation of the protein-protein interaction interface and is involved in the regulation of protein import and export. The coiled-coil region of IFT-2 is responsible for the protein's stability and stability. It is also involved in the regulation of protein import and export.

The C-terminal T-spike domain of IFT-2 is responsible for the protein's ability to interact with the intracellular side of the membrane. It is involved in the regulation of protein import and export and is thought to play a key role in the regulation of intracellular signaling.

IFT complex also includes the protein known as IFT-3 (intraflagellar transport complex subunit 3), which is a 20-kDa protein that is involved in the transport of VAP molecule import and export. It consists of a N-terminal transmembrane domain, a coiled-coil region, and a C-terminal T-spike domain.

The N-terminal transmembrane domain of IFT-3 is responsible for the protein's ability to interact with the cytoplasmic side of the membrane. It is involved in the formation of the protein-protein interaction interface and is involved in the regulation of protein import and export. The coiled-coil region of IFT-3 is responsible for the protein's stability and stability. It is also involved in the regulation of protein import and export.

In conclusion, IFT complex is a well-established protein complex that plays a critical role in the transport of organelles within cells. The IFT complex is composed of several proteins that work together to ensure efficient and accurate transport of these organelles. The most well-studied protein in the IFT complex is IFT-1, which is involved in the transport of mitochondrial protein import and export. IFT-2 and IFT-3 are also involved in the transport of ER and VAP proteins, respectively. The regulation of protein import and export by IFT complex is important for the proper functioning of various cellular processes, including intracellular signaling, protein transport, and cell signaling. Therefore, IFT complex is a potential drug target and a biomarker for various diseases.

Protein Name: Intraflagellar Transport Complex

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